FUNCTIONAL MEDICINE BLOG
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Migraine and histamine intolerance, with a link to MS
Histamine is involved in the pathogenesis of both migraine and multiple sclerosis (NS).
Wine and histamine intolerance
Wine and histamine intolerance can be associated with an array of symptoms depending the degree of impairment of DAO (diamine oxidase) activity and the characteristics of the wine... For patients whose presentation suggests histamine intolerance aggravated by wine, consider assessing DAO activity and compensating with supplemented DAO for impaired production if indicated; the use of flavonoid compounds, notably quercitin; and a suggestion to seek wines higher in polyphenolic and flavonoid compounds.
Histamine intolerance
Histamine intolerance is a widespread phenomenon that can mimic allergy. It plays a role in many diverse conditions including IBS and inflammatory bowel diseases, asthma, postural orthostatic tachycardia syndrome (POTS), complications of pregnancy, drug hypersensitivity, and intestinal permeability (by means of which it contributes to autoimmunity). It can be objectively evaluated with serum DAO activity. HI can be ameliorated by supplementation with DAO. Practitioners need to be astute in its diagnosis and management.