Inflammatory Bowel Disease, Interleukin-10 Receptors & Vitamin D

This is one reason why some people need much more Vitamin D than the usual reference level. This paper just published in The New England Journal of Medicine describes the link between inflammatory bowel disease (an autoimmune condition) and mutations affecting the Interleukin-10 receptor. Here's the connection: IL-10 is an anti-inflammatory cytokine is produced by regulatory T cells. Production of regulatory T cells requires vitamin D. Earlier research has disclosed genetic polymorphisms (variations) in vitamin D receptors; now it's clear we can also have polymorphisms for IL-10 receptors. Folks, notice how many different diseases have an autoimmune component. Make sure your vitamin D is optimal, not barely adequate.