FUNCTIONAL MEDICINE BLOG
Includes over 800 monographs reporting on emerging studies in the medical and scientific literature of practical clinical importance, easily searched for content.
Leaky gut: inflammation, chronic fatigue and depression
Leaky gut permits bacterial LPS translocation into the gut lymphoid tissue where it triggers inflammation causing chronic fatigue and depression.
Breast cancer, oxidative stress and NF-κB
A paper just published in the journal Breast Cancer Research and Treatment highlights how reactive oxygen species (ROS) activate pro-inflammatory NF-κB (nuclear factor kappa beta, also an oncogenic transcription factor) to promote more aggressive breast cancer, and that this can be ameliorated by NAC.
Blood from children with autism induces autistic features in rats
"One of the most remarkable findings of the current study is the development of several features of autism in young rats whose brains were exposed to sera from autistic children...Remarkably, P6 treatment was able to rescue these structural abnormalities probably via increased BDNF expression."
Traumatic brain injury and chronic neuroinflammation
Traumatic brain injury (TBI) even in it's milder forms can initiate a process of chronic neuroinflammation that causes a range of chronic neurodegenerative disorders. ..Judicious application of natural anti-inflammatory agents to minimize side-effects along with other measures guided by objective measurements is a standard for treating traumatic brain injury that can be applied to other neurodegenerative disorders as well.
Antioxidants in excess can increase inflammation and blunt benefits of exercise
Antioxidants, even glutathione, taken in excess can increase rather than ameliorate harmful inflammation...The use of antioxidants must be calibrated with careful consideration of the balance between protective and suppressive effects according to the needs of the individual patient.