12/29/15 12/29/15

Circadian rhythms of inflammation

Treatment of chronic inflammation can be enhanced and adrenal suppression minimized by circadian dosing of anti-inflammatory medication.

8/31/15 8/31/15

Adrenal suppression by inhaled steroids is common

A clinical study just published in the European Journal of Endocrinology offers evidence that inhaled steroids...frequently cause serious adrenal suppression. They also show that simply measuring morning cortisol can help indicate whether adrenal insufficiency is occurring.

8/10/15 8/10/15

Inhaled steroids may worsen asthma with air pollution

Research recently published in the Journal of Allergy and Clinical Immunology demonstrates that inhaled corticosteroids may in fact worsen asthma in the presence of CO (carbon monoxide).

6/21/14 6/21/14

Antioxidants in excess can increase inflammation and blunt benefits of exercise

Antioxidants, even glutathione, taken in excess can increase rather than ameliorate harmful inflammation...The use of antioxidants must be calibrated with careful consideration of the balance between protective and suppressive effects according to the needs of the individual patient.

11/3/13 11/3/13

Wine and histamine intolerance

Wine and histamine intolerance can be associated with an array of symptoms depending the degree of impairment of DAO (diamine oxidase) activity and the characteristics of the wine... For patients whose presentation suggests histamine intolerance aggravated by wine, consider assessing DAO activity and compensating with supplemented DAO for impaired production if indicated; the use of flavonoid compounds, notably quercitin; and a suggestion to seek wines higher in polyphenolic and flavonoid compounds.

10/5/13 10/5/13

Histamine intolerance

Histamine intolerance is a widespread phenomenon that can mimic allergy. It plays a role in many diverse conditions including IBS and inflammatory bowel diseases, asthma, postural orthostatic tachycardia syndrome (POTS), complications of pregnancy, drug hypersensitivity, and intestinal permeability (by means of which it contributes to autoimmunity). It can be objectively evaluated with serum DAO activity. HI can be ameliorated by supplementation with DAO. Practitioners need to be astute in its diagnosis and management.

10/6/12 10/6/12

Acute gastrointestinal infection can turn on autoimmune disorders

Autoimmune disorders can be promoted by a variety of factors that must be considered in case management.Acute gastrointestinal infection—such as a food-borne illness or viral gastroenteritis—can cause the immune system to lose tolerance for commensal bacteria (the ones that normally live in the intestines), contributing to the development of autoimmune disorders.