FUNCTIONAL MEDICINE BLOG
Includes over 800 monographs reporting on emerging studies in the medical and scientific literature of practical clinical importance, easily searched for content.
Migraine and histamine intolerance, with a link to MS
Histamine is involved in the pathogenesis of both migraine and multiple sclerosis (NS).
Cognitive decline: major overlooked causes
Cognitive decline is fueled by that have not received adequate attention but have great practical, clinical significance.
Wine and histamine intolerance
Wine and histamine intolerance can be associated with an array of symptoms depending the degree of impairment of DAO (diamine oxidase) activity and the characteristics of the wine... For patients whose presentation suggests histamine intolerance aggravated by wine, consider assessing DAO activity and compensating with supplemented DAO for impaired production if indicated; the use of flavonoid compounds, notably quercitin; and a suggestion to seek wines higher in polyphenolic and flavonoid compounds.
Histamine intolerance
Histamine intolerance is a widespread phenomenon that can mimic allergy. It plays a role in many diverse conditions including IBS and inflammatory bowel diseases, asthma, postural orthostatic tachycardia syndrome (POTS), complications of pregnancy, drug hypersensitivity, and intestinal permeability (by means of which it contributes to autoimmunity). It can be objectively evaluated with serum DAO activity. HI can be ameliorated by supplementation with DAO. Practitioners need to be astute in its diagnosis and management.
Progesterone and irritable bowel syndrome, headaches and irritable bladder
Progesterone plays a role in preventing or ameliorating irritable bowel syndrome by inhibiting the release of histamine. This applies to numerous conditions including migraine, interstitial cystitis (painful/irritable bladder), dysmenorrhea and others.