The 5-day fasting mimicking diet is well tolerated and causes remarkable systemic metabolic changes in patients with different tumor types It reshapes systemic and intratumor immunity and activates several antitumor immune programs.

Anti-idiotype antibodies (Ab2 antibodies) are produced by the immune system as a means to tame to effect of the ‘original’ antibodies (Ab1 antibodies) induced to react to a specific antigen to prevent the immune response from getting out of hand. The SARS-CoV-2 spike protein antigen is one such primary Ab1 target.

SARS-CoV-2, like many other infections, can trigger latent or instigate new autoimmunity. It is exceptional compared to many other pathogens in the large number of epitopes (the part of an antigen that an antibody attaches to) that mimic human antigens. This includes targets for brain inflammation.

High insulin levels, provoked by spikes in blood glucose due to high glycemic foods or stress chemistry, block the metabolism of calories for energy and force them to be stored as visceral fat. This process precedes weight gain.

Diffuse, non-specific symptoms are experienced years before the diagnostic criteria for multiple sclerosis (MS) are satisfied. This illustrates the ‘prodrome’ that is typical of a wide variety of autoimmune disorders. It highlights the importance of investigating antibodies to self-tissue (autoantibodies) classified as ‘predictive’ when they occur before any symptoms.

Natural killer (NK) cells are specialized white blood cells crucial for fighting cancer and a first line of defense against infection. Robust activity of NK cells is necessary to keep cancer cells dormant and oppose metastasis. New evidence has emerged showing how metabolic factors that promote liver fibrosis result in the suppression of healthy NK cell activity.