Children and fatty liver disease

Parents, if your children are overweight it is prudent to protect them by having their liver enzymes measured. Non-alcoholic fatty liver disease (NAFLD) is being seen much more frequently in children due to the marked increase in metabolic syndrome associated with being overweight. This paper published in the journal GUT (International Journal of Gastroenterology and Hepatology) "aimed at determining the long-term outcomes and survival of children with NAFLD." Liver biopsies were obtained when indicated. The investigators documented a disturbing progression to end-stage liver disease and liver transplantation: "Children with NAFLD may develop end-stage liver disease with the consequent need for liver transplantation. NAFLD in children...may be associated with a significantly shorter survival as compared to the general population.". Their findings are encouragement to help children eat well and exercise. What is the key: "Insulin resistance is almost a universal finding in paediatric NAFLD."