FUNCTIONAL MEDICINE BLOG
Includes over 800 monographs reporting on emerging studies in the medical and scientific literature of practical clinical importance, easily searched for content.
Leaky gut: inflammation, chronic fatigue and depression
Leaky gut permits bacterial LPS translocation into the gut lymphoid tissue where it triggers inflammation causing chronic fatigue and depression.
Gluten intolerance acquired after gastroenteritis
Gluten intolerance can occur at any age due to a number of causes that contribute to loss of immune tolerance. The authors of a paper published recently in the journal Gastroenterology and Hepatology from Bed to Bench remind how a bout of viral or bacterial gastroenteritis can be the trigger.
Histamine intolerance
Histamine intolerance is a widespread phenomenon that can mimic allergy. It plays a role in many diverse conditions including IBS and inflammatory bowel diseases, asthma, postural orthostatic tachycardia syndrome (POTS), complications of pregnancy, drug hypersensitivity, and intestinal permeability (by means of which it contributes to autoimmunity). It can be objectively evaluated with serum DAO activity. HI can be ameliorated by supplementation with DAO. Practitioners need to be astute in its diagnosis and management.
Progesterone and irritable bowel syndrome, headaches and irritable bladder
Progesterone plays a role in preventing or ameliorating irritable bowel syndrome by inhibiting the release of histamine. This applies to numerous conditions including migraine, interstitial cystitis (painful/irritable bladder), dysmenorrhea and others.
Non-celiac gluten sensitivity
Celiac disease is but one consequence of autoimmunity or autoinflammation triggered by gluten among a host of others better characterized by the term non-celiac gluten sensitivity (NCGS). The lack of standardization in terminology has obscured this fact, so two recent papers that help to clear the air are welcome.
Persistent gastrointestinal symptoms demand a look at the brain-gut axis
Persistent gastrointestinal symptoms demand a look at the brain-gut axis
Diarrhea without infection or allergy can be due to autoimmune pancreatic insufficiency
Diarrhea without infection or allergy can be due to autoimmune pancreatic insufficiency