FUNCTIONAL MEDICINE BLOG
Includes over 800 monographs reporting on emerging studies in the medical and scientific literature of practical clinical importance, easily searched for content.
Stroke risk reduced by magnesium
Stroke risk is reduced by higher plasma magnesium levels according to data from 32,826 women in the Nurses’ Health Study presented in a paper just published in the journal Stroke.
Nuts reduce inflammation and all-cause mortality
In the absence of allergy, the evidence supports the consumption of nuts as wholesome foods with anti-inflammatory and metabolic benefits, exactly what paleo diets intend to accomplish.
Prediabetes also damages the heart
A study just published in the journal Circulation demonstrates that prediabetes causes unfelt damage to the heart that substantially raises the risk of future coronary artery disease and heart failure regardless of cholesterol levels.
Nigella sativa, a true 'wonder medicine'?
Nigella sativa, also known as black cumin, produces seeds with a mind-boggling wealth of medicinal virtues. For colleagues and others who may not be familiar with the abundance of scientific evidence for the use of Nigella sativa seed extract in clinical practice, this selection of citations serves as an introduction to its wide range of indications.
Statins — how they increase diabetes risk
Knowing that statins activate the NLRP3/caspase-1 inflammasome that promotes inflammation and insulin resistance should caution practitioners to attend carefully to insulin sensitivity in patients taking statins.
Magnesium supplementation improves insulin resistance
Insulin resistance is benefited by magnesium supplementation according to mounting evidence. A study published in the journal Diabetes, Obesity and Metabolism documents significant improvements in insulin resistance by supplementation even when the subjects' magnesium levels appeared normal.
Walking in the evening improves cardiovascular markers better than walking in the morning
Walking is beneficial any time of day, but an interesting study published recently in the journal Preventive Medicine demonstrated significantly more improvement in some key cardiovascular lipid and inflammatory markers by walking in the evening versus in the morning.
Exercise: moderation is best for the heart
Exercise can benefit with surprisingly little effort and time as documented by recent studies, but like everything else there is a dose-response curve, meaning that the effect of exercise varies with the dose (intensity, duration). Now there is more evidence that exercising too intensively can do harm, particularly to the cardiovascular system.
Thyroid in heart, metabolism, brain, kidney; vital importance of T3
Thyroid disorders have widespread impact and although subclinical hypothyroidism and low triiodothyronine (T3) syndrome are common they are frequently overlooked in practice.
Magnesium: insulin, brain, heart and inflammation
Magnesium may be the critical nutrient most commonly drained by modern environmental stress to suboptimal levels... Recent studies add evidence to its indication for insulin resistance, diabetes, cognitive impairment, atrial fibrillation, cardiovascular disease, and neurogenic inflammation.
Atrial fibrillation risk increased by non-steroidal antiinflammatory drugs
NSAIDs increased the risk for atrial fibrillation. Practitioners must bear in mind the potential for all non-steroidal anti-inflammatory drugs to cause atrial fibrillation by aggravating or triggering latent autoimmune inflammation due to gut barrier compromise.
Metabolic health status and aging determined by inflammation, not weight
Metabolic health is not reliably determined by weight or BMI (body mass index). Lean individuals can suffer from cardiovascular and other diseases involving metabolism, and evidence has been mounting that supports the notion of a subtype of obesity that is metabolically healthy. Inflammation can determine metabolic health in both obese and non-obese populations.
Vagal nerve activity moderates brain-immune relationships and is measured by heart rate variability
An exciting study with tremendous practical significance was just published in the Journal of Neuroimmunology that shows how vagal nerve activity, which can be measured in the clinic by heart rate variability analysis (HRV), is a key moderator of the brain-immune web and determines the immune and physiological responses to acute stress.
Aspirin Cardiovascular/Gastrointestinal Risk Calculator
Aspirin has been shown to be worthy of consideration for secondary, and in some cases primary, prevention of heart attacks and strokes but carries known risks for gastrointestinal side effects. If you're not certain whether to recommend low-dose aspirin to a patient, the aspirin cardiovascular/gastrointestinal risk calculator can help with the clinical decision. A paper recently published in the journal Alimentary Pharmacology and Therapeutics describes the development and use of this practical tool.
Treating atherosclerosis as an autoimmune inflammatory disease
Atherosclerosis is a disease characterized by plaque formation in an artery in response to inflammation in the lining (endothelium) of the vessel. It is referred to also as vulnerable plaque because it is subject to rupture followed by the blocking of a smaller downstream artery, the immediate cause of most heart attacks and strokes. A paper recently published in Immunology Letters discusses the treatment of the vascular inflammation of atherosclerosis as an autoimmune inflammatory disorder.
High protein beats high carbohydrate diet for biomarkers of metabolic syndrome
Regulating insulin is the key factor metabolic syndrome, diabetes and weight loss. In accordance with that, a randomized controlled trial just published in the journal Diabetes Care offers more evidence that a higher protein (with carbohydrate) diet improves multiple biomarkers better than a high carbohydrate diet.
Erectile Dysfunction is a risk factor for cardiovascular disease and mortality
More evidence that erectile dysfunction is a risk factor for cardiovascular disease is presented in a study just published in PLoS Medicine (Public Library of Science). This should come as no surprise considering that health of vascular endothelium is one of the elements necessary to ensure blood delivery to the 'periphery'. The authors added to literature on this topic by examining the degree of erectile dysfunction in relation to cardiovascular risk.
More evidence supports restraint with calcium supplementation
An extensive study just published in BMJ (British Medical Journal) offers more evidence* that higher levels of calcium intake can increase the risk of death from cardiovascular disease, ischemic heart disease and all causes.
Data shows high intake of omega-6 fatty acids is not advised for cardiovascular health
Research recently published in BMJ (British Medical Journal) examines accumulated data to reveal that advice given by the American Heart Association to increase consumption of omega-6 fatty acids, particularly linolenic acid found in corn, sunflower, safflower, and soybean oils, is misguided for cardiovascular health.