11/25/16 11/25/16

Thyroid disorders in children and adolescents: clinical review

11/1/16 11/1/16

Levothyroxine therapy and normal TSH yet hypothyroid symptoms

A significant proportion of patients treated with levothyroxine continue to experience residual symptoms of hypothyroidism, including psychological and metabolic effects, due to inadequate conversion of T4 to T3.

5/12/16 5/12/16

Mood disorders and thyroid autoimmunity

Mood disorders and thyroid autoimmunity are linked by aberrant levels of hematopoietic/neuronal growth factors...even before hypothyroidism has developed, and also in relatives of thyroid autoimmunity subjects, growth factors necessary for healthy brain function are at levels associated with a range of mood disorders including bipolar, depression and psychosis. They also include an important reminder that antibodies can predict clinical disease years in advance.

11/23/15 11/23/15

Thyroid hormone conversion affects hypothyroid treatment

Dosing strategies solely based on a TSH definition of euthyroidism neglect the important role of FT3, which has recently emerged as an equally significant parameter in defining thyroid physiology... in cases where an FT3–FT4 dissociation becomes increasingly apparent following dose escalation of l-T4, an alternate treatment modality, possibly T3/T4 combination therapy, should be considered.

11/28/14 11/28/14

Vertigo and dizziness associated with thyroid autoimmunity

Vertigo and dizziness can occur when the vestibular system (parts of the inner ear and brain that process sensory information to control balance and eye movements) is disturbed. "...the present study demonstrates the existence of a clear relationship between thyroid autoimmunity and subclinical vestibular damage, regardless of thyroid function. "

11/13/14 11/13/14

Subclinical hypothyroidism in pregnancy

Subclinical hypothyroidism has been associated with multiple adverse maternal, fetal, and neonatal outcomes...On the basis of current evidence, we believe it is reasonable to recommend treating women with new onset subclinical hypothyroidism during pregnancy.

5/5/14 5/5/14

Thyroid autoimmunity affects cognitive and emotional function

Autoimmune thyroiditis is "associated with cognitive and affective disorders also in the euthyroid [normal thyroid hormone level] state. Thereby thyroid antibodies might play a direct role or indicate an autoimmune process."

2/27/14 2/27/14

Bipolar disorder and neuroinflammation

There is a massive amount of evidence supporting the importance of assessing and treating neuroinflammation in bipolar disorder and other neuropsychiatric illnesses. This makes necessarily the comprehensive examination of autoimmunity and its numerous underlying contributory causes.

9/10/13 9/10/13

Autism and autoimmunity: more evidence

6/29/13 6/29/13

Iodine deficiency, pregnancy, and autoimmunity

Iodine deficiency is still a serious concern, especially for pregnant women in North America, as reported in a review just published in the journal Thyroid. Despite global improvements since 1990, iodine sufficiency has actually been declining in US adults. Iodine deficiency can be detected with a 24-hour urine collection. Even when supplementation is indicated it must be done cautiously to avoid triggering autoimmune thyroiditis.

3/1/13 3/1/13

Study associates iodine deficiency with type 2 diabetes

Astute clinicians are cautious with iodine supplementation due to the risk for triggering latent thyroid autoimmunity, but a study just published in the journal Experimental and Clinical Endocrinology & Diabetes is a reminder to remain vigilant about the potential need for iodine when managing type 2 diabetes.